Transforming Growth Factor β-1 Induces Snail Transcription Factor in Epithelial Cell Lines

TGFβ induces Snail transcription factor Transforming growth factor beta 1 induces Snail transcription factor in epithelial cell lines. Mechanisms for Epithelial Mesenchymal Transitions

Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.

The Snail transcription factor has been described recently as a strong repressor of E-cadherin in epithelial cell lines, where its stable expression leads to the loss of E-cadherin expression and induces epithelial-mesenchymal transitions and an invasive phenotype. The mechanisms regulating Snail expression in development and tumor progression are not yet known. We show here that transforming g...

Effect of Transforming Growth Factor-β (TGF-β) on proliferation of gastric epithelial cells in culture

Objective: Helicobacter pylori has a well-established role in the development of gastric cancer. In vitro studies reveal increased proliferation of the gastric mucosa in the presence of H. pylori infection. It has been also shown that production of some cytokines, such as interleukin-1 beta (IL-1b) is in...

Transforming Growth Factor β/activin signalling induces epithelial cell flattening during Drosophila oogenesis

Although the regulation of epithelial morphogenesis is essential for the formation of tissues and organs in multicellular organisms, little is known about how signalling pathways control cell shape changes in space and time. In the Drosophila ovarian epithelium, the transition from a cuboidal to a squamous shape is accompanied by a wave of cell flattening and by the ordered remodelling of E-cad...

effect of transforming growth factor-β (tgf-β) on proliferation of gastric epithelial cells in culture

objective: helicobacter pylori has a well-established role in the development of gastric cancer. in vitro studies reveal increased proliferation of the gastric mucosa in the presence of h. pylori infection. it has been also shown that production of some cytokines, such as interleukin-1 beta (il-1b) is increased in h. pylori infection. in addition, il-1b increases proliferation of gastric epithe...